闾军，女，1969年出生。浙江大学医学院博士毕业，美国NIH(National Institute of Health)博士后。多年来一直从事内科、传染病的临床医疗、教学和科研工作。曾获得国家发明专利1项，美国NIH技术转让1项。2006年回国后开展了肿瘤的生物治疗，如肿瘤的基因治疗，通过肿瘤局部、动脉灌注等各种给药方式提高基因制剂对肿瘤的杀伤效应，对多种肿瘤都有良好的治疗效果。目前承担国家“863”计划课题，北京市自然科学基金等多项研究课题，获得北京市优秀人才、北京市卫生人才“十百千”培养以及教育部回国留学人员培养资助，近年来以第一作者在Blood, Journal of Infectious Diseases、PLoS ONE等专业杂志上发表SCI论文7篇，共发表论文20余篇。现任首都医科大学附属北京佑安医院、首都医科大学第九临床医学院肿瘤生物治疗科科主任，副主任医师，硕士研究生导师。
擅长各种肿瘤疾病的基因治疗、细胞免疫治疗、生物靶向治疗及内科综合治疗；对各种肝炎、肝炎相关性再障疾病有自己的经验和方法；病毒性、酒精性、药物性及自身免疫性肝病的诊断和内科综合治疗。
论文发表：
1. Melenhorst JJ, Scheinberg P, Lu J, Ambrozak DR, Sosa E, Zhao L, Hensel NF, Savani BN, Douek DC, Price DA, Barrett AJ. Regulatory T-cell depletion does not prevent emergence of new CD25+ FOXP3+ lymphocytes after antigen stimulation in culture. Cytotherapy. 2008;10(2):152-64.
2. Filippone C, Zhi N, Wong S, Lu J, Kajigaya S, Gallinella G, Kakkola L, Söderlund-Venermo M, Young NS, Brown KE. VP1u phospholipase activity is critical for infectivity of full-length parvovirus B19 genomic clones. Virology. 2008 Feb 4。
3. An X, Lu J(co-first author), Huang JD, Zhang B, Liu D, Zhang X, Chen J, Zhou Y, Tong Y. Rapid assembly of multiple-exon cDNA directly from genomic DNA. PLoS ONE. 2007 Nov 14;2(11):e1179.
4. Jun Lu, Ning Zhi, Susan Wong, and Kevin E. Brown. Activation of Synoviocytes by the Secreted Phospholipase A2 Motif in the VP1-Unique Region of Parvovirus B19 Minor Capsid Protein. J Infect Dis, 2006 Feb 15;193(4):582-90.
5. Ning Zhi, Ian P. Mills, Jun Lu, Susan Wong, Claudia Filippone, and Kevin E. Brown. Molecular and Functional Analyses of a Human Parvovirus B19 Infectious Clone Demonstrates Essential Roles for NS1, VP1, and the 11-Kilodalton Protein in Virus Replication and Infectivity. J Virol, 2006 Jun;80(12):5941-50.
6. Sloand EM, Mainwaring L, Fuhrer M, Ramkissoon S, Risitano AM, Keyvanafar K, Lu J, Basu A, Barrett AJ, Young NS. Preferential suppression of trisomy 8 compared with normal hematopoietic cell growth by autologous lymphocytes in patients with trisomy 8 myelodysplastic syndrome. Blood. 2005 Aug 1;106(3):841-51.
7. Li CY, Zhan YQ, Xu CW, Xu WX, Wang SY, Lv J, Zhou Y, Yue PB, Chen B, Yang XM. EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-kappa B. Cell Death Differ. 2004 Dec;11(12):1299-308.
8. Jun Lu, Atanu Basu, Jan Melenhorst, Neal S. Young and Kevin E. Brown. Analysis of T cell repertoire in hepatitis-associated aplastic anemia. Blood. 2004 Jun 15;103(12):4588-93.
9. Lu J, Xu WX, Zhan YQ, Cui XL, Cai WM, He FC, Yang XM. Identification and characterization of a novel isoform of hepatopoietin. World J Gastroenterol. 2002 Apr;8(2):353-6
10. 闾军, 许望翔, 詹轶群, 崔晓林, 蔡为民, 贺福初, 杨晓明. 一种新的肝细胞生成素(HPO)转录本及其生物学活性. 生物化学与生物物理学报. 2002 Mar;34(2):225-30.
11. 闾军, 胡敏君, 蔡为民. 慢性肝病患者外周血间质胶原酶(MMP-1)及其抑制剂(TIMP-1)基因表达的研究. 临床肝胆病杂志. 2002 Feb; 18(1): 31-32.
12. 闾军, 许望翔, 汪思应, 江岩, 李长燕, 蔡为民, 杨晓明. 在NIH3T3细胞中高表达EDAG-1基因导致细胞恶性转化. 生物化学与生物物理学报. 2002 Jan;34(1):95-8.
13. Jiang Y, Xu W, Lu J, He F, Yang X. Invasiveness of hepatocellular carcinoma cell lines: contribution of hepatocyte growth factor, c-met, and transcription factor Ets-1. Biochem Biophys Res Commun 2001 Sep 7; 286(5): 1123-30.
14. 闾军, 许望翔, 汪思应, 詹轶群, 江岩, 蔡为民, 杨晓明. EDAG-1, 一种与造血调控密切相关新基因的分离和确认. 生物化学与生物物理学报. 2001;33(6):641-646.
韩大康 副主任医师
首都医科大学附属北京佑安医院 肿瘤生物治疗科
病毒性肝炎、脂肪肝、酒精性肝病，药物性肝损害治疗