李华伟,教授,博士研究生导师。
国家杰出青年科学基金和上海市第一批浦江学者人才计划获得者。李华伟教授是我国著名耳鼻喉-头颈外科学家王正敏院士培养的博士后,获得上海市优秀博士后称号。2002年赴美国哈佛大学医学院眼耳医院学习深造,重点研究听觉医学,2004年被哈佛大学医学院附属眼耳医院聘为研究员(Principal Investigator)。现为复旦大学附属眼耳鼻喉科医院耳鼻喉科教授,《美国耳鼻喉研究学会》会员、《临床耳鼻咽喉科杂志》编委、《听力学及言语疾病杂志》编委。
李华伟教授参与完成的“耳外科神经功能的保护和重建”项目获国家科技进步奖二等奖(2005年)、“耳显微外科及其相关基础研究”项目获2003年中华医学科技奖二等奖和2003年上海市科技进步二等奖。以第一完成人主持的“内耳发育及毛细胞再生的研究”项目2004年经过上海市科委组织的鉴定,评定为“国际领先水平”。
作为课题负责人承担着国家杰出青年科学基金、国家自然科学基金、上海市浦江学者人才计划、上海市重点基础研究项目、上海市科委科研基金、卫生部课题基金、国家教委博士点课题、中国博士后科研基金等项目。
以第一作者在国内外核心期刊发表听觉医学和听觉修复相关研究论文30余篇,包括自然-医学(Nature Medicine)、美国科学院学报(Proceedings of National Academy of Sciences,PNAS)、分子医学进展(Trends in Molecular Medicine)等十余篇SCI收录的国际著名科技期刊论文(其中4篇论文获得封面照片和重点介绍的第一导读,1篇获得本期明星图片),并被引用100余次。
李华伟教授具有丰富的耳鼻咽喉-头颈外科疾病临床诊疗经验,尤其在耳外科方面有较深的造诣。主要临床特长:耳显微外科、耳神经-颅底外科、耳聋及眩晕的防治,在急、慢性中耳炎的手术治疗,耳肿瘤、耳畸形和耳硬化症的听力重建手术,面瘫的显微外科治疗等方面有特长。
代表性论文:
- Huawei Li, Hong Liu, and Stefan Heller. Pluripotent stem cells from the adult mouse inner ear. Nature Medicine. 2003; 9(10): 1293-1299. (Cover story,封面). Impact factor: 31.223.
- Huawei Li, Graham Roblin1, Hong Liu, and Stefan Heller. Generation of hair cells by stepwise differentiation of embryonic stem cells. Proceedings of National Academy of Sciences (PNAS), 2003; 100(23): 13495-13500. (Cover story,封面).Impact factor: 10.252.
- Huawei Li, C. Eduardo Corrales, Albert Edge, and Stefan Heller. Stem Cells for Therapy of Hearing Loss. Trends in Molecular Medicine. 2004, 10(7): 309-315.(Cover story,封面). Impact factor: 7.497.
- Huawei Li, Hong Liu, Cyrille Sage, Mingqian Huang, Zheng-Yi Chen, Stefan Heller. Islet-1 expression in the developing chicken inner ear. Journal of Comparative Neurology, 2004, 477: 1-10. (Cover story,封面). Impact factor: 3.4.
- Huawei Li, Hong Liu, C. Eduardo Corrales, Hideki Mutai, and Stefan Heller. Correlation of Pax-2 Expression with Cell Proliferation in the Developing Chicken Inner Ear. Journal of Neurobiology. 2004,60(1):61-70. Impact factor: 3.923.
- Huawei Li, Hong Liu, Steve Balt, Sabine Mann, C. Eduardo Corrales and Stefan Heller. Correlation of expression of the actin filament-bundling protein espin with stereociliary bundle formation in the developing inner ear. Journal of Comparative Neurology, 2004, 468(1): 125-134. Impact factor: 3.4.
- Zhengmin Wang, Huawei Li, Fanglu Chi, Houyong Li, and Yunzheng Sheng. Bax Involvement in Neuronal Cell Apoptosis of Spiral Ganglion in Postnatal Rat. Acta Otolaryngol (Stockh), 2001, 121(7): 777-780. Impact factor: 0.87.
- Zhengmin Wang and HuaweiLi. Microglia-like Cells in rat Organ of Corti Following Aminoglycoside Ototoxicity. NeuroReport. 2000; 11(7): 1389-1393. Impact factor: 2.351.
- Huawei Li*, C. Eduardo Corrales, Zhengmin Wang, Yanling Zhao, Yucheng Wang, Sabine Mann, Hong Liu, and Stefan Heller. BMP4 signaling is involved in the generation of inner ear sensory epithelia. BMC Dev Biol. 2005, 17;5(1):16. (Image of the month, 本期明星图片). (*通讯作者)
- Hongmeng Yu, Huawei Li, Fanglu Chi, Chunfu Dai, Chonghua Zhang and Zhengmin Wang. Endoscopic Surgery with Powered instrumentation for Isolated Sphenoid Sinus Disease. Oto-Rhino-Laryngology and Its Related Specialties. 2005, In press.
- Zhengmin Wang*, Hongqun Jiang, Yongbing Yan, Yucheng Wang, Yunzheng Shen, Wen Li, and Huawei Li*. Characterization of proliferating cells from newborn mouse cochleae. 2006. (*通讯作者)
- Yanling Zhao, Yucheng Wang, Zhengmin Wang, Yunzheng Shen, and Huawei Li*.Shh promotes mouse inner ear progenitor cell proliferation and hair cell generation. NeuroReport 2006, Impact factor: 2.351.
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